XBP1 polyclonal antibody
产品名称： XBP1 polyclonal antibody
英文名称： XBP1 polyclonal antibody
产品编号： PAB13182
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of XBP1.
- Immunogen:
- A synthetic peptide corresponding to 18 amino acids near N-terminus of human XBP1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-2 ug/mL)
Immunocytochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D.Nature. 2002 Jan 3;415(6867):92-6.
- 2.
- Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.
Haze K, Yoshida H, Yanagi H, Yura T, Mori K.Mol Biol Cell. 1999 Nov;10(11):3787-99.
- 3.
- The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications.
Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS.Crit Rev Eukaryot Gene Expr. 1994;4(1):1-18.
- Entrez GeneID:
- 7494
- Protein Accession#:
- BAB82982
- Gene Name:
- XBP1
- Gene Alias:
- TREB5,XBP2
- Gene Description:
- X-box binding protein 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq
- Other Designations:
- OTTHUMP00000028682,X-box-binding protein-1
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