MAGEA4 (N-term) Peptide
产品名称： MAGEA4 (N-term) Peptide
英文名称： MAGEA4 (N-term) Peptide
产品编号： P1774
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAGEA4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MAGEA4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity.
Nagao T, Higashitsuji H, Nonoguchi K, Sakurai T, Dawson S, Mayer RJ, Itoh K, Fujita J.J Biol Chem. 2003 Mar 21;278(12):10668-74. Epub 2003 Jan 13.
- 2.
- Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas.
Resnick MB, Sabo E, Kondratev S, Kerner H, Spagnoli GC, Yakirevich E.Int J Cancer. 2002 Sep 10;101(2):190-5.
- 3.
- Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.
Imai Y, Shichijo S, Yamada A, Katayama T, Yano H, Itoh K.Gene. 1995 Jul 28;160(2):287-90.
- Applications
- Western Blot (Cell lysate)
- The MAGEA4 polyclonal antibody (Cat # PAB4746) is used in Western blot to detect MAGEA4 in A-375 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MAGEA4 polyclonal antibody (Cat # PAB4746) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4103
- Protein Accession#:
- P43358
- Gene Name:
- MAGEA4
- Gene Alias:
- MAGE-41,MAGE-X2,MAGE4,MAGE4A,MAGE4B,MGC21336
- Gene Description:
- melanoma antigen family A, 4
- Omim ID:
- 300175
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000025889,OTTHUMP00000025890,melanoma-associated antigen 4