NSD1 (Human) Recombinant Protein (Q01)
产品名称： NSD1 (Human) Recombinant Protein (Q01)
英文名称： NSD1 (Human) Recombinant Protein (Q01)
产品编号： H00064324-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human NSD1 partial ORF ( NP_071900, 2 a.a. - 109 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- DQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQT
- Theoretical MW (kDa):
- 37.62
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 64324
- GeneBank Accession#:
- NM_022455
- Protein Accession#:
- NP_071900
- Gene Name:
- NSD1
- Gene Alias:
- ARA267,DKFZp666C163,FLJ10684,FLJ22263,FLJ44628,KMT3B,SOTOS,STO
- Gene Description:
- nuclear receptor binding SET domain protein 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
- Other Designations:
- androgen receptor-associated coregulator 267
- Gene Pathway
- Related Disease
- Abnormalities, Multiple
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Chromosome Breakage
- Chromosome Deletion
- Craniofacial Abnormalities
- Developmental Disabilities
- Endocrine System Diseases
- Facies
- Gigantism
- Growth Disorders
- Mental Disorders
- Mental Retardation
- Motor Skills
- Neuropsychological Tests
- Syndrome