GDF15 (N-term) Peptide
产品名称： GDF15 (N-term) Peptide
英文名称： GDF15 (N-term) Peptide
产品编号： P0854
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GDF15.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human GDF15.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- KRASG12V Enhances Proliferation and Initiates Myelomonocytic Differentiation in Human Stem/Progenitor Cells via Intrinsic and Extrinsic Pathways.
Fatrai S, van Gosliga D, Han L, Daenen SM, Vellenga E, Schuringa JJ.J Biol Chem. 2011 Feb 25;286(8):6061-70. Epub 2010 Dec 17.
- 2.
- Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
Paralkar VM, Vail AL, Grasser WA, Brown TA, Xu H, Vukicevic S, Ke HZ, Qi H, Owen TA, Thompson DD.J Biol Chem. 1998 May 29;273(22):13760-7.
- 3.
- PLAB, a novel placental bone morphogenetic protein.
Hromas R, Hufford M, Sutton J, Xu D, Li Y, Lu L.Biochim Biophys Acta. 1997 Oct 9;1354(1):40-4.
- 4.
- Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta.
Yokoyama-Kobayashi M, Saeki M, Sekine S, Kato S.J Biochem. 1997 Sep;122(3):622-6.
- Applications
- Western Blot (Cell lysate)
- The GDF15 polyclonal antibody (Cat # PAB3883) is used in Western blot to detect GDF15 in A-375 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with GDF15 polyclonal antibody (Cat # PAB3883) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 9518
- Protein Accession#:
- GDF15_HUMAN
- Gene Name:
- GDF15
- Gene Alias:
- GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB
- Gene Description:
- growth differentiation factor 15
- Omim ID:
- 605312
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Bone morphogenetic proteins (e.g., BMP5; MIM 112265) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM
- Other Designations:
- NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1,PTGF-beta,prostate differentiation factor
- Related Disease
- Adenoma
- Adenomatous Polyps
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- Alzheimer disease
- Carcinoma
- Cardiovascular Diseases
- Colorectal Neoplasms
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hypertension
- Hypertrophy, Left Ventricular
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasm Metastasis
- Neoplasms
- Osteoporosis
- Prostate cancer