Anti-CACNA2D2 Polyclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司--实验室产品
Anti-CACNA2D2 Polyclonal Antibody

Anti-CACNA2D2 Polyclonal Antibody

商家询价

产品名称: Anti-CACNA2D2 Polyclonal Antibody

英文名称: CACNA2D

产品编号: K007989P

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: null

使用范围: IHC

北京索莱宝科技有限公司--实验室产品
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Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.