http://www.creativebiomart.net/description_382835_12.htm

Immunoglobulin superfamily member 8, also known as IGSF8, PGRL, and CD316, is a single-pass membrane protein with a short cytoplasmic domain interacting with membrane PIPs and mediating plasma membrane localization. It is expressed in brain, kidney, testic, liver and placenta with moderate expression in all other tissues. This protein has been detected on a majority of B-cells, T-cells, and nature killer cells but not on monocytes, polynuclear cells and platelets. IGSF8 may play a role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. It also regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. It may also play a role on integrin-dependent morphology and motility functions and participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.